Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer

Gunasinghe, N.P.A. Devika, Wells, Alan, Thompson, Erik W., & Hugo, Honor J. (2012) Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. Cancer and Metastasis Reviews, 31(3-4), pp. 469-478.

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Abstract

As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort has been concentrated on understanding the processes of metastasis, how a primary tumour locally invades and systemically disseminates using the phenotypic switching mechanism of epithelial to mesenchymal transition (EMT); however, much less is understood about how metastases are then formed. Breast cancer metastases often look (and may even function) as 'normal' breast tissue, a bizarre observation against the backdrop of the organ structure of the lung, liver, bone or brain. Mesenchymal to epithelial transition (MET), the opposite of EMT, has been proposed as a mechanism for establishment of the metastatic neoplasm, leading to questions such as: Can MET be clearly demonstrated in vivo? What factors cause this phenotypic switch within the cancer cell? Are these signals/factors derived from the metastatic site (soil) or expressed by the cancer cells themselves (seed)? How do the cancer cells then grow into a detectable secondary tumour and further disseminate? And finallyCan we design and develop therapies that may combat this dissemination switch? This review aims to address these important questions by evaluating long-standing paradigms and novel emerging concepts in the field of epithelial mesencyhmal plasticity.

Impact and interest:

110 citations in Scopus
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102 citations in Web of Science®

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ID Code: 72218
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):29
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 22729277
Additional URLs:
Keywords: Breast cancer, EMT, Epithelial, Mesenchymal, MET, Metastasis, Proliferation, Transition
DOI: 10.1007/s10555-012-9377-5
ISSN: 1573-7233
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 29 May 2014 02:48
Last Modified: 29 Aug 2016 07:36

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