Soiling the seed : microenvironment and epithelial mesenchymal plasticity

Haviv, Izhak & Thompson, Erik W. (2012) Soiling the seed : microenvironment and epithelial mesenchymal plasticity. Cancer Microenvironment, 5(1), pp. 1-3.

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Abstract

In the past decade we have come to appreciate that the microenvironment has the potential for major influence on the cancer cell. An extreme case for this occurs when the cancer cell changes its environment in the context of metastasis, where this may in part underpin the altered biology of cells in metasases. Increasing evidence suggests that changes in the cellular microenvironment contribute to tumourigenesis and metastasis, but the molecular basis of these alterations is not well understood. Reactive stroma provides oncogenic signals to facilitate tumourigenesis and metastasis—co-implantation of normal human epithelial cells in vivo with irradiated, carcinogen treated, or cancer derived fibroblasts leads to the enhancement or formation of malignant tumours.

Impact and interest:

4 citations in Scopus
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ID Code: 72219
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):4
Export Date: 6 May 2014
Source: Scopus
Additional URLs:
DOI: 10.1007/s12307-012-0104-0
ISSN: 1875-2284
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 29 May 2014 02:52
Last Modified: 30 May 2014 02:06

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