Factors regulating basement membrane invasion by tumor cells
Thompson, E.W., Reich, R., Martin, G.R., & Albini, A. (1988) Factors regulating basement membrane invasion by tumor cells. In Lippman, M.E. & Dickson, R.B. (Eds.) Breast Cancer : Cellular and Molecular Biology. Springer, Boston, MA, pp. 239-249.
Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells.
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|Item Type:||Book Chapter|
|Additional Information:||Cited By (since 1996):3
Export Date: 6 May 2014
PubMed ID: 2908653
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Deposited On:||29 May 2014 03:02|
|Last Modified:||29 May 2014 03:02|
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