Factors regulating basement membrane invasion by tumor cells

Thompson, E.W., Reich, R., Martin, G.R., & Albini, A. (1988) Factors regulating basement membrane invasion by tumor cells. In Lippman, M.E. & Dickson, R.B. (Eds.) Breast Cancer : Cellular and Molecular Biology. Springer, Boston, MA, pp. 239-249.

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Basement membranes serve as significant barriers to the passage of tumor cells but ones which metastatic cells can pass. This involves the production of a cascade of proteases leading to the activation of a specific collagenase that degrades the unique collagen network in basement membrane. Breast cancer cells, when estrogen dependent, show a requirement for estrogen for invasive activity. However, when these cells progress to an estrogen independent state and increased malignancy, they express an invasive phenotype constitutively. Studies with various anti-estrogens suggest that these responses are mediated via the estrogen receptor. Anti-estrogens lacking agonist activity suppress invasiveness as well as growth of the breast cancer cells.

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ID Code: 72221
Item Type: Book Chapter
Additional Information: Cited By (since 1996):3
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 2908653
Additional URLs:
ISBN: 9781461317333
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 29 May 2014 03:02
Last Modified: 29 May 2014 03:02

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