Preclinical drug development must consider the impact on metastasis

Steeg, Patricia S., Anderson, Robin L., Bar-Eli, Menashe, Chambers, Ann F., Eccles, Suzanne A., Hunter, Kent W., Itoh, Kazuyuki, Kang, Yibin, Matrisian, Lynn M., Sleeman, Jonathan P., Theodorescu, Dan, Thompson, Erik W., & Welch, Danny R. (2009) Preclinical drug development must consider the impact on metastasis. Clinical Cancer Research, 15(14), pp. 4529-4530.

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Abstract

Recently, two landmark reports on antiangiogenic therapy were published: Paez-Ribes and colleagues and Ebos and colleagues . The Board of the Metastasis Research Society (MRS) congratulates the authors for their informative articles that help to explain the puzzle of why antiangiogenic agents have had a relatively minor or no significant impact on patient survival. Using four model systems and several different strategies, these researchers showed that inhibition of angiogenesis reduced primary tumor growth and microvessel density in keeping with many earlier reports, but strikingly, accelerated invasion and metastasis.

Impact and interest:

25 citations in Scopus
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24 citations in Web of Science®

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ID Code: 72224
Item Type: Journal Article
Refereed: Yes
Additional Information:

Articles free to read on journal website after 12 months

Cited By (since 1996):19
Export Date: 6 May 2014
Source: Scopus

Additional URLs:
DOI: 10.1158/1078-0432.CCR-09-1363
ISSN: 1557-3265
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 29 May 2014 01:50
Last Modified: 29 Jan 2015 05:13

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