Invasive activity and chemotactic response to growth factors by Kaposi's sarcoma cells

Albini, Adriana, Mitchell, Charles D., Thompson, Erik W., Seeman, Ruth, Martin, George R., Wittek, Alec E., & Quinnan, Gerald V. (1988) Invasive activity and chemotactic response to growth factors by Kaposi's sarcoma cells. Journal of Cellular Biochemistry, 36(4), pp. 369-376.

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Abstract

Kaposi's sarcoma (KS) is a relatively low grade neoplasm, classically occurring in the skin of elderly men. A more virulent and invasive form of Kaposi's sarcoma has been described in patients with acquired immune deficiency syndrome (AIDS). The origin and identification of the tumor cells in these lesions is controversial. Here we have studied the behavior of cells derived from KS lesions in an in vitro assay which measures the ability of cells to invade through a reconstituted basement membrane. In agreement with previous work, KS cells obtained under selective culture conditions were invasive showing activity comparable to that of malignant tumor cells. Normal fibroblasts, smooth muscle cells, and endothelial cells did not demonstrate invasive behavior under the same experimental conditions. To characterize further the nature of the KS cells we tested the chemotactic response of cells from the most invasive line to a variety of growth factors and compared their response to those of fibroblasts, smooth muscle, and endothelial cells. These studies suggest that normal cells respond to a unique repertoire of chemotactic factors. The chemotactic response of the KS cells most closely resembled that of smooth muscle cells and was quite distinct from endothelial cells. These results indicate that the KS-derived cultures contain invasive cells with a smooth muscle cell-like phenotype.

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21 citations in Scopus
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36 citations in Web of Science®

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ID Code: 72303
Item Type: Journal Article
Refereed: Yes
Keywords: Kaposi's sarcoma; chemotaxis; invasion; growth factors
DOI: 10.1002/jcb.240360406
ISSN: 0730-2312
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 02 Jun 2014 05:02
Last Modified: 02 Jun 2014 05:02

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