The biology of breast tumor progression : acquisition of hormone independence and resistance to cytotoxic drugs
Leonessa, F., Boulay, V., Wright, A., Thompson, Erik W., Brunner, N., & Clarke, R. (1992) The biology of breast tumor progression : acquisition of hormone independence and resistance to cytotoxic drugs. Acta Oncologica, 31(2), pp. 115-123.
Many breast tumors appear to follow a predictable clinical pattern, being initially responsive to endocrine therapy and to cytotoxic chemotherapy but ultimately exhibiting a phenotype resistant to both modalities. Using the MCF-7 human breast cancer cell line as an example of an 'early' phenotype (estrogen and progesterone receptor positive, steroid responsive, low metastatic potential), we have isolated and characterized a series of hormone-independent but hormone-responsive variants (MIII and MCF7/LCC1). However, these variants remain responsive to both antiestrogens and cytotoxic drugs (methotrexate and colchicine). MIII and MCF7/LCCl cells appear to mimic some of the critical aspects of the early progression to a more aggressive phenotype. An examination of the phenotype of these cells suggests that some hormone-independent breast cancer cells are derived from hormone-dependent parental cells. The development of a hormone-independent phenotype can arise independently of acquisition of a cytotoxic drug resistant phenotype.
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|Item Type:||Journal Article|
|Keywords:||Breast cancer, Cell biology, Progression|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||03 Jun 2014 04:18|
|Last Modified:||03 Jun 2014 04:18|
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