The biology of breast tumor progression : acquisition of hormone independence and resistance to cytotoxic drugs

Leonessa, F., Boulay, V., Wright, A., Thompson, Erik W., Brunner, N., & Clarke, R. (1992) The biology of breast tumor progression : acquisition of hormone independence and resistance to cytotoxic drugs. Acta Oncologica, 31(2), pp. 115-123.

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Many breast tumors appear to follow a predictable clinical pattern, being initially responsive to endocrine therapy and to cytotoxic chemotherapy but ultimately exhibiting a phenotype resistant to both modalities. Using the MCF-7 human breast cancer cell line as an example of an 'early' phenotype (estrogen and progesterone receptor positive, steroid responsive, low metastatic potential), we have isolated and characterized a series of hormone-independent but hormone-responsive variants (MIII and MCF7/LCC1). However, these variants remain responsive to both antiestrogens and cytotoxic drugs (methotrexate and colchicine). MIII and MCF7/LCCl cells appear to mimic some of the critical aspects of the early progression to a more aggressive phenotype. An examination of the phenotype of these cells suggests that some hormone-independent breast cancer cells are derived from hormone-dependent parental cells. The development of a hormone-independent phenotype can arise independently of acquisition of a cytotoxic drug resistant phenotype.

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32 citations in Web of Science®

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ID Code: 72520
Item Type: Journal Article
Refereed: Yes
Keywords: Breast cancer, Cell biology, Progression
ISSN: 0284-186X
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 03 Jun 2014 04:18
Last Modified: 03 Jun 2014 04:18

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