Mechanisms of tumour invasion and metastasis : emerging targets for therapy

Price, John T. & Thompson, Erik W. (2002) Mechanisms of tumour invasion and metastasis : emerging targets for therapy. Expert Opinion on Therapeutic Targets, 6(2), pp. 217-233.

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The progression of a tumour from one of benign and delimited growth to one that is invasive and metastatic is the major cause of poor clinical outcome in cancer patients. The invasion and metastasis of tumours is a highly complex and multistep process that requires a tumour cell to modulate its ability to adhere, degrade the surrounding extracellular matrix, migrate, proliferate at a secondary site and stimulate angiogenesis. Knowledge of the process has greatly increased and this has resulted in the identification of a number of molecules that are fundamental to the process. The involvement of these molecules has been shown to relate not only to the survival and proliferation of the tumour cell but, also to the processes of tumour cell adhesion, migration, and the tumour cells ability to degrade and escape the primary site as well as play a role in angiogenesis. These molecules may provide important therapeutic targets that represent the ability to target specific steps in the process of invasion and metastasis and provide additional therapies. The review focuses on representative key targets in each of these processes and summarises the state of play in each case.

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ID Code: 72542
Item Type: Journal Article
Refereed: Yes
Keywords: Adhesion, Cadherins, Focal adhesion kinase, Growth factors, Integrins, Invasion, Matrix metalloproteinases, Metastasis, Migration, Phosphatidylinositol 3 kinase, Phospholipase C, Proteases, u-PAR
DOI: 10.1517/14728222.6.2.217
ISSN: 1472-8222
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 04 Jun 2014 01:33
Last Modified: 04 Jun 2014 01:33

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