Assays for the study of human cancer cell invasion and metastasis

Frandsen, T. L., Boysen, B. E., Jirus, S., Zwiebel, J., Spang-Thomsen, M., Thompson, Erik W., & Brunner, N. (1992) Assays for the study of human cancer cell invasion and metastasis. Fibrinolysis, 6(Supp 4), pp. 71-76.

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Two in vitro and two in vivo assays for the study of human cancer invasion and metastasis are described. The assays include in vitro invasiveness through an artificial basement membrane (Matrigel®), invasiveness and metastasis in nude mice of subcutaneously injected LacZ-transduced human tumor cells, in vitro adherence to basement membrane components, and LacZ-transduced human cancer cells injected intravenously into nude mice. In studies of the processes involved in human cancer cell invasion and metastasis, these four assays were found to be complementary, and thus provide a set of test systems for preclinical screening of agents which interfere with these processes.

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ID Code: 72548
Item Type: Journal Article
Refereed: Yes
ISSN: 1369-0191
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 03 Jun 2014 23:53
Last Modified: 03 Jun 2014 23:54

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