High level of MT-MMP expression is associated with invasiveness of cervical cancer cells

Gilles, Christine, Polette, Myriam, Piette, Jacques, Munaut, Carine, Thompson, Erik W., Birembaut, Philippe, & Foidart, Jean-Michel (1996) High level of MT-MMP expression is associated with invasiveness of cervical cancer cells. International Journal of Cancer, 65(2), pp. 209-213.

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MMP-2 (gelatinase A) has been associated with the invasive potential of many cancer cells both in vitro and in vivo. It is now becoming clear that the activation of this enzyme might be a key step in tumor invasion. This activation process has been shown to be a membrane-associated pathway inducible by various agents such as collagen type I, concanavalin A or TGF-β, but its physiological regulation is still largely unresolved. MT-MMP was recently discovered and described as a potential gelatinase-A activator. In the present study, we investigated the expression of MT-MMP (membrane-type metalloproteinase) in cervical cancer cells both in vitro and in vivo. Comparing several in vitro-transformed cervical cell lines, previously shown to display different invasive potentials, our results showed that the ability of cells to overexpress MT-MMP mRNA following ConA induction correlated with their ability to activate gelatinase A and with a highly invasive behavior. Moreover, using immunohistochemistry and in situ hybridization, we found a higher level of MT-MMP expression in invasive cervical carcinoma and lymphnode metastases compared to its expression in non-invasive CIN III lesions. Our in vivo observations also clearly demonstrated a cooperation between stromal and tumor cells for the production of MT-MMP. Taken together, our results clearly correlated high level MT-MMP expression with invasiveness, and thus suggested that MT-MMP might play a crucial role in cervical tumor invasion.

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148 citations in Scopus
141 citations in Web of Science®
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ID Code: 72562
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):141
Export Date: 6 May 2014
Source: Scopus
PubMed ID: 8567119
Additional URLs:
DOI: 10.1002/(SICI)1097-0215(19960117)65:2<209::AID-IJC14>3.0.CO;2-8
ISSN: 1097-0215
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 04 Jun 2014 04:08
Last Modified: 04 Jun 2014 04:08

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