Regulation of breast cancer cells by hormones and growth factors : effects on proliferation and basement membrane invasiveness

Thompson, Erik W., Martin, M. B., Saceda, M., Clarke, R., Brunner, N., Lippman, M. E., & Dickson, R. B. (1989) Regulation of breast cancer cells by hormones and growth factors : effects on proliferation and basement membrane invasiveness. Hormone Research, 32(Supp 1), pp. 242-249.

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Abstract

The current understanding of the regulation of breast cancer cell proliferation and invasiveness by hormones and growth factors is reviewed. It has been shown that polypeptide growth factors are involved in hormone-independent breast cancer, and are sometimes oestrogen-regulated in hormone-responsive models. Basement-membrane invasiveness, relating to the metastatic potential of these cells, is also stimulated by oestrogen in hormone-dependent models, elevated in hormone-independent models, and is growth factor sensitive. Further understanding of the differential effects of growth factors on breast cancer cell proliferation and invasiveness should facilitate better therapeutic exploitation of regulation at this level.

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14 citations in Scopus
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16 citations in Web of Science®

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ID Code: 72568
Item Type: Journal Article
Refereed: Yes
DOI: 10.1159/000181356
ISSN: 0301-0163
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 04 Jun 2014 23:02
Last Modified: 04 Jun 2014 23:02

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