Hormones and breast cancer in vitro

Dickson, R. B., Thompson, Erik W., & Lippman, M. E. (1989) Hormones and breast cancer in vitro. Human cell : official journal of Human Cell Research Society, 2(3), pp. 219-230.


Breast cancer is characterized by hormonal regulation. The current article reviews the role of estrogen and polypeptide growth factors in control of proliferation and basement membrane invasion of breast cancer cells in vitro. The role of antiestrogens to regulate proliferation, invasion, and growth factor secretion is further highlighted. Finally, the use of in vitro cultures of breast cancer cells to model steps in the malignant progression of the disease is emphasized. The availability of hormone dependent and independent breast cancer cell lines should allow screening for better antiestrogens, antimetastatic drugs, and antagonists of local action of growth factors.

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7 citations in Scopus
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ID Code: 72569
Item Type: Journal Article
Refereed: Yes
ISSN: 0914-7470
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 05 Jun 2014 04:11
Last Modified: 05 Jun 2014 04:11

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