Induction of tumorigenicity by galectin-3 in a nontumorigenic human breast-carcinoma cell-line

Nangia-Makker, P., Thompson, Erik W., Hogan, C., Ochieng, J., & Raz, A. (1995) Induction of tumorigenicity by galectin-3 in a nontumorigenic human breast-carcinoma cell-line. International Journal of Oncology, 7(5), pp. 1079-1087.

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The human galectin-3 is a galactoside-binding protein of 31 kDa which functions as a receptor for glycoproteins containing poly N-acetyllactosamine side chains and as a substrate for matrix metalloproteinases-2 and -9. We studied its expression by flow cytofluorimetry, Western, Northern and Southern analyses, in five cultured human breast carcinoma cell lines previously characterized as non-tumorigenic, poorly metastatic or metastatic in nude mice. The expression of galectin-3 correlated with the reported tumorigenicity of the cells. The introduction of recombinant galectin-3 into the null expressing non-tumorigenic BT-549 cells resulted in the acquisition of anchorage-independent growth properties in alland tumorigenicity in 3/4 sense transfected cell crones. The data indicate a relationship between galectin-3 expression and malignancy of human breast carcinoma cell lines.

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ID Code: 72576
Item Type: Journal Article
Refereed: Yes
Keywords: Breast cancer, Galectin-3, Lectin, Transfection, Tumorigenicity
DOI: 10.3892/ijo.7.5.1079
ISSN: 1019-6439
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 04 Jun 2014 04:23
Last Modified: 04 Jun 2014 04:23

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