Formation of blood clot on biomaterial implants influences bone healing

Shiu, Hoi Ting, Goss, Ben, Cameron, Lutton, Crawford, Ross, & Xiao, Yin (2014) Formation of blood clot on biomaterial implants influences bone healing. Tissue Engineering, Part B: Reviews, 20(6), pp. 697-712.

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The first step in bone healing is forming a blood clot at injured bones. During bone implantation, biomaterials unavoidably come into direct contact with blood, leading to a blood clot formation on its surface prior to bone regeneration. Despite both situations being similar in forming a blood clot at the defect site, most research in bone tissue engineering virtually ignores the important role of a blood clot in supporting healing. Dental implantology has long demonstrated that the fibrin structure and cellular content of a peri-implant clot can greatly affect osteoconduction and de novo bone formation on implant surfaces. This paper reviews the formation of a blood clot during bone healing in related to the use of platelet-rich plasma (PRP) gels. It is implicated that PRP gels are dramatically altered from a normal clot in healing, resulting conflicting effect on bone regeneration. These results indicate that the effect of clots on bone regeneration depends on how the clots are formed. Factors that influence blood clot structure and properties in related to bone healing are also highlighted. Such knowledge is essential for developing strategies to optimally control blood clot formation, which ultimately alter the healing microenvironment of bone. Of particular interest are modification of surface chemistry of biomaterials, which displays functional groups at varied composition for the purpose of tailoring blood coagulation activation, resultant clot fibrin architecture, rigidity, susceptibility to lysis, and growth factor release. This opens new scope of in situ blood clot modification as a promising approach in accelerating and controlling bone regeneration.

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8 citations in Scopus
9 citations in Web of Science®
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ID Code: 72584
Item Type: Journal Article
Refereed: Yes
Keywords: blood clot, platelet-rich plasma (PRP) gels, bone healing
DOI: 10.1089/ten.teb.2013.0709
ISSN: 2152-4955
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Mary Ann Liebert, Inc.
Deposited On: 21 Jan 2015 00:38
Last Modified: 21 Jun 2017 14:02

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