Epithelial-to-mesenchymal transitions and circulating tumor cells

Bonnomet, Arnaud, Brysse, Anne, Tachsidis, Anthony, Waltham, Mark, Thompson, Erik W., Polette, Myriam, & Gilles, Christine (2010) Epithelial-to-mesenchymal transitions and circulating tumor cells. Journal of Mammary Gland Biology and Neoplasia, 15(2), pp. 261-273.

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Abstract

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival.

Impact and interest:

129 citations in Scopus
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109 citations in Web of Science®

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ID Code: 72699
Item Type: Journal Article
Refereed: Yes
Keywords: CTC, EMT, Metastases
DOI: 10.1007/s10911-010-9174-0
ISSN: 1573-7039
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 10 Jun 2014 05:48
Last Modified: 11 Jun 2014 00:33

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