Epithelial-to-mesenchymal transitions and circulating tumor cells
Bonnomet, Arnaud, Brysse, Anne, Tachsidis, Anthony, Waltham, Mark, Thompson, Erik W., Polette, Myriam, & Gilles, Christine (2010) Epithelial-to-mesenchymal transitions and circulating tumor cells. Journal of Mammary Gland Biology and Neoplasia, 15(2), pp. 261-273.
Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival.
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|Item Type:||Journal Article|
|Keywords:||CTC, EMT, Metastases|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||10 Jun 2014 05:48|
|Last Modified:||11 Jun 2014 00:33|
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