Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids

Dickson, Robert B., Thompson, Erik W., & Lippman, Marc E. (1990) Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. Journal of Steroid Biochemistry and Molecular Biology, 37(3), pp. 305-316.

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Endogenous ovarian estrogens and progestins appear to play a critical role in the development and progression of breast cancer. Local productions of growth factors probably also contribute to malignant proliferation, while production and activation of collagenolytic enzymes may be equally critical for local invasive processes. The current review focusses on characterization of growth factor-receptor systems operant in normal and malignant breast epithelium. In addition, the determinants of local invasion are reviewed: attachment, modality, and proteose secretion. Finally, data are discussed concerning the regulation of both proliferation and invasion by hormones and antihormonal agents in hormone-dependent breast cancer. The results suggest new potential pharmacologic targets to explore to suppress onset and progression of breast cancer.

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74 citations in Scopus
81 citations in Web of Science®
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ID Code: 72703
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/0960-0760(90)90479-5
ISSN: 0960-0760
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 10 Jun 2014 05:28
Last Modified: 21 Jun 2017 15:01

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