CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents

Trezise, Ann E.O., Linder, Carol C., Grieger, David, Thompson, Erik W., Meunier, Hélène, Griswold, Michael D., & Buchwald, Manual (1993) CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents. Nature Genetics, 3(2), pp. 157-164.

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Abstract

Severely reduced fertility is a common finding in cystic fibrosis (CF). We used in situ hybridization to examine the cell-specific expression of CFTR in the reproductive organs of rodents. In males CFTR mRNA is found in the round spermatids (spermatogenic stages V-X) and in the principal cells that line the initial segment of the epididymis. In both the testis and the epididymis, CFTR expression is developmentally regulated suggesting that the defect in the genital tract of male CF patients is of developmental origin. CFTR expression in the luminal and glandular epithelium of the uterus is regulated during the oestrous cycle and is maximal at pro-oestrus. Our results provide a biological rationale for the reduced fertility of CF patients, and suggest a possible cause for the comparatively poorer prognosis for women with CF.

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ID Code: 72720
Item Type: Journal Article
Refereed: Yes
DOI: 10.1038/ng0293-157
ISSN: 1546-1718
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 12 Jun 2014 01:21
Last Modified: 12 Jun 2014 01:21

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