Adipose tissue induction in vivo

Stillaert, F.B.J.L., Blondeel, P., Hamdi, M., Abberton, K., Thompson, E.W., & Morrison, W.A. (2007) Adipose tissue induction in vivo. Advances in Experimental Medicine and Biology : Tissue Engineering, 585, pp. 403-412.

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Abstract

Engineering adipogenic tissue in vivo requires the concomitant induction of angiogenesis to generate a stable long-term three-dimensional construct. Histiocon-ductive tissue engineering strategies have been used. The disadvantage of using biodegradable scaffolds is a delayed angiogenic induction resulting in ischemic necrosis of the central cell population in the scaffold. We evaluated an histioinductive approach for adipose tissue engineering by combining essential key components for adipogenic induction:

(1) a precursor cell source;

(2) a vascular pedicle;

(3) a supportive matrix, and;

(4) a chamber to preserve space for the new tissue to develop.

We observed concomitant adipogenic and angiogenic induction after 6 weeks in three-dimensional adipose tissue constructs.

Impact and interest:

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ID Code: 72730
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By (since 1996):12
Export Date: 6 May 2014
Source: Scopus
Additional URLs:
DOI: 10.1007/978-0-387-34133-0_26
ISSN: 0065-2598
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 11 Jun 2014 03:54
Last Modified: 16 Jun 2014 07:11

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