Radiosensitizing effect of electrochemotherapy in a fractionated radiation regimen in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model

Kranjc, S., Tevz, G., Kamensek, U., Vidic, S., Cemazar, M., & Sersa, G. (2009) Radiosensitizing effect of electrochemotherapy in a fractionated radiation regimen in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model. Radiation Research, 172(6), pp. 677-685.

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Abstract

Radiosensitizing Effect of Electrochemotherapy in a Fractionated Radiation Regimen in Radiosensitive Murine Sarcoma and Radioresistant Adenocarcinoma Tumor Model. Electrochemotherapy can potentiate the radiosensitizing effect of bleomycin, as shown in our previous studies. To bring this treatment closer to use in clinical practice, we evaluated the interaction between electrochemotherapy with bleomycin and single-dose or fractionated radiation in two murine tumor models with different histology and radiosensitivity. Radiosensitive sarcoma SA-1 and radioresistant adenocarcinoma CaNT subcutaneous tumors grown in A/J and CBA mice, respectively, were used. The anti-tumor effect and skin damage around the treated tumors were evaluated after electrochemotherapy with bleomycin alone or combined with single-dose radiation or a fractionated radiation regimen. The anti-tumor effectiveness of electrochemotherapy was more pronounced in SA-1 than CaNT tumors. In both tumor models, the tumor response to radiation was not significantly influenced by bleomycin alone or by electroporation alone. However, electrochemotherapy before the first tumor irradiation potentiated the response to a single-dose or fractionated radiation regimen in both tumors. For the fractionated radiation regimen, normal skin around the treated tumors was damaged fourfold less than for the single-dose regimen. Electrochemotherapy prior to single-dose irradiation induced more damage to the skin around the treated tumors and greater loss of body weight compared to other irradiated groups, whereas electrochemotherapy combined with the fractionated radiation regimen did not. Electrochemotherapy with low doses of bleomycin can also be used safely for radiosensitization of different types of tumors in a fractionated radiation regimen, resulting in a good anti-tumor effect and no major potentiating effect on radiation-induced skin damage. © 2009 by Radiation Research Society.

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ID Code: 73287
Item Type: Journal Article
Refereed: Yes
Keywords: bleomycin, animal cell, animal experiment, animal model, animal tissue, antineoplastic activity, article, breast adenocarcinoma, cancer inhibition, cancer radiotherapy, cancer resistance, controlled study, electrochemotherapy, female, low drug dose, male, mouse, nonhuman, priority journal, radiation dose fractionation, radiosensitivity, sarcoma, skin injury, Adenocarcinoma, Animals, Antineoplastic Agents, Combined Modality Therapy, Disease Models, Animal, Dose Fractionation, Mice, Mice, Inbred CBA, Radiation Tolerance, Sarcoma, Experimental, Murinae, Mus
DOI: 10.1667/RR1873.1
ISSN: 00337587 (ISSN)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 08 Jul 2014 00:44
Last Modified: 08 Jul 2014 23:11

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