Improving the detection of donations within the RHD negative blood donor panel which weakly express the RHD antigen
Nagl, Lisa P. (2014) Improving the detection of donations within the RHD negative blood donor panel which weakly express the RHD antigen. Masters by Research thesis, Queensland University of Technology.
This project improved the detection and classification of very weakly expressed RhD variants in the Australian blood donor panel and contributed to the knowledge of anti-D reactivity patterns of RHD alleles that are undescribed. As such, the management of donations possessing these RHD alleles can be improved upon and the overall safety of transfusion medicine pertaining to the Rh blood group system will be increased. Future projects at ARCBS will be able to utilise the procedures developed in this project, thereby decreasing throughput time. The specificity of current testing will be improved and the need for outsourced RHD testing diminished.
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|Item Type:||QUT Thesis (Masters by Research)|
|Supervisor:||Hafner, Louise, Flower, Robert, & Hyland, Cate|
|Keywords:||DEL, RHD, anti-D, genotyping, adsorption elution, K409K, qPCR, epitope, transfusion, minor groove binding|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Institution:||Queensland University of Technology|
|Deposited On:||18 Jul 2014 04:56|
|Last Modified:||04 Sep 2015 02:29|
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