Improving the detection of donations within the RHD negative blood donor panel which weakly express the RHD antigen

Nagl, Lisa P. (2014) Improving the detection of donations within the RHD negative blood donor panel which weakly express the RHD antigen. Masters by Research thesis, Queensland University of Technology.


This project improved the detection and classification of very weakly expressed RhD variants in the Australian blood donor panel and contributed to the knowledge of anti-D reactivity patterns of RHD alleles that are undescribed. As such, the management of donations possessing these RHD alleles can be improved upon and the overall safety of transfusion medicine pertaining to the Rh blood group system will be increased. Future projects at ARCBS will be able to utilise the procedures developed in this project, thereby decreasing throughput time. The specificity of current testing will be improved and the need for outsourced RHD testing diminished.

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168 since deposited on 18 Jul 2014
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ID Code: 73333
Item Type: QUT Thesis (Masters by Research)
Supervisor: Hafner, Louise, Flower, Robert, & Hyland, Cate
Keywords: DEL, RHD, anti-D, genotyping, adsorption elution, K409K, qPCR, epitope, transfusion, minor groove binding
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 18 Jul 2014 04:56
Last Modified: 04 Sep 2015 02:29

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