Carbon nanostructures for hard tissue engineering

Jun Han, Zhao, Rider, Amanda E., Ishaq, Musarat, Kumar, Shailesh, Kondyurin, Alexey, Bilek, Marcela M. M., Levchenko, Igor, & Ostrikov, Kostya (2013) Carbon nanostructures for hard tissue engineering. RSC Advances, 3(28), pp. 11058-11072.

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The primary goal in hard tissue engineering is to combine high-performance scaffold materials with living cells to develop biologically active substitutes that can restore tissue functions. This requires relevant knowledge in multidisciplinary fields encompassing chemical engineering, material science, chemistry, biology and nanotechnology. Here we present an overview on the recent progress of how two representative carbon nanostructures, namely, carbon nanotubes and graphene, aid and advance the research in hard tissue engineering. The article focuses on the advantages and challenges of integrating these carbon nanostructures into functional scaffolds for repairing and regenerative purposes. It includes, but is not limited to, the critical physico-chemical properties of carbon nanomaterials for enhanced cell interactions such as adhesion, morphogenesis, proliferation and differentiation; the novel designs of two- and three-dimensional nanostructured scaffolds; multifunctional hybrid materials; and the biocompatible aspects of carbon nanotubes and graphene. Perspectives on the future research directions are also given, in an attempt to shed light on the innovative and rational design of more effective biomedical devices in hard tissue engineering.

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18 citations in Scopus
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15 citations in Web of Science®

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ID Code: 73574
Item Type: Journal Article
Refereed: Yes
DOI: 10.1039/c2ra23306a
ISSN: 2046-2069
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 09 Jul 2014 01:51
Last Modified: 10 Jul 2014 02:03

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