Assessing the role of spatial correlations during collective cell spreading

Treloar, Katrina, Simpson, Matthew, Binder, Benjamin J., McElwain, Sean, & Baker, Ruth (2014) Assessing the role of spatial correlations during collective cell spreading. Scientific Reports, 4, 5713-1---8.

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Abstract

Spreading cell fronts are essential features of development, repair and disease processes. Many mathematical models used to describe the motion of cell fronts, such as Fisher’s equation, invoke a mean–field assumption which implies that there is no spatial structure, such as cell clustering, present. Here, we examine the presence of spatial structure using a combination of in vitro circular barrier assays, discrete random walk simulations and pair correlation functions. In particular, we analyse discrete simulation data using pair correlation functions to show that spatial structure can form in a spreading population of cells either through sufficiently strong cell–to–cell adhesion or sufficiently rapid cell proliferation. We analyse images from a circular barrier assay describing the spreading of a population of MM127 melanoma cells using the same pair correlation functions. Our results indicate that the spreading melanoma cell populations remain very close to spatially uniform, suggesting that the strength of cell–to–cell adhesion and the rate of cell proliferation are both sufficiently small so as not to induce any spatial patterning in the spreading populations.

Impact and interest:

7 citations in Scopus
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9 citations in Web of Science®

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ID Code: 73608
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Cell spreading, Cell diffusivity, Cell proliferation rate, Cancer, Wound healing
DOI: 10.1038/srep05713
ISSN: 2045-2322
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2014 Nature Publishing Group
Deposited On: 10 Jul 2014 00:06
Last Modified: 15 Sep 2014 22:40

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