Molecular network analysis using reverse phase protein microarrays for patient tailored therapy.

Speer, Runa, Wulfkuhle, Julia, Espina, Virginia, Aurajo, Robyn, Edmiston, Kirsten H., Liotta, Lance A., & Petricoin, Emanuel F. (2008) Molecular network analysis using reverse phase protein microarrays for patient tailored therapy. In Colotta, Francesco & Mantovani, Alberto (Eds.) Targeted Therapies in Cancer : Myth or Reality? Springer New York, New York, pp. 177-186.

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Abstract

The practice of medicine has always aimed at individualized treatment of disease. The relationship between patient and physician has always been a personal one, and the physician's choice of treatment has been intended to be the best fit for the patient's needs. The necessary pooling/grouping of disease families and their assignment to a number of drugs or treatment methods has, consequently, led to an increase in the number of effective therapies. However, given the heterogeneity of most human diseases, and cancer specifically, it is currently impossible for the treating clinician to effectively predict a patient's response and outcome based on current technologies, much less the idiosyncratic resistances and adverse effects associated with the limited therapeutic options.

Impact and interest:

10 citations in Scopus
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11 citations in Web of Science®

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ID Code: 73612
Item Type: Book Chapter
Keywords: cancer, oncology
DOI: 10.1007/978-0-387-73898-7_13
ISBN: 978-0-387-73897-0
ISSN: 0065-2598
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Mathematical Sciences
Deposited On: 10 Jul 2014 01:12
Last Modified: 27 Oct 2015 16:10

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