Nanoparticles in cancer imaging and therapy

Smith, Leon, Kuncic, Zdenka, Ostrikov, Kostya, & Kumar, Shailesh (2012) Nanoparticles in cancer imaging and therapy. Journal of Nanomaterials, 2012, Article ID 891318.

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Abstract

Nanoparticle contrast agents offer the potential to significantly improve existing methods of cancer diagnosis and treatment. Advantages include biocompatibility, selective accumulation in tumor cells, and reduced toxicity. Considerable research is underway into the use of nanoparticles as enhancement agents for radiation therapy and photodynamic therapy, where they may be used to deliver treatment agents, produce localized enhancements in radiation dose and selectively target tumor cells for localized damage. This paper reviews the current status of nanoparticles for cancer treatment and presents preliminary results of a pilot study investigating titanium dioxide nanoparticles for dual-mode enhancement of computed tomography (CT) imaging and kilovoltage radiation therapy. Although titanium dioxide produced noticeable image contrast enhancement in the CT scans, more sensitive detectors are needed to determine whether the nanoparticles can also produce localized dose enhancement for targeted radiation therapy.

Impact and interest:

14 citations in Scopus
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10 citations in Web of Science®

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ID Code: 73617
Item Type: Journal Article
Refereed: Yes
DOI: 10.1155/2012/891318
ISSN: 1687-4129
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: 2012 Leon Smith et al.
Copyright Statement: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deposited On: 09 Jul 2014 03:01
Last Modified: 01 Dec 2016 05:20

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