The pathobiology of mammographic density

Britt, Kara, Ingman, Wendy, Huo, Cecilia, Chew, Grace, & Thompson, Erik (2014) The pathobiology of mammographic density. Journal of Cancer Biology & Research, 2(1), p. 1021.

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Abstract

High mammographic density confers a significantly increased risk of breast cancer. As it is relatively common in the normal population the risk of cancer attributable to increased mammographic density could potentially account for an important percentage of total BCa cases. The underlying cause for high mammographic density and its association with increased BCa risk and progression is unknown. In this review we describe the work that has been done to define the histopathological characteristics of mammographic density. Mammograms define breast tissues with areas of high density due to an increased amount of radio-opaque tissue (stromal and epithelial cells) and also less areas of radiolucent fat. Histological work however can define the roles played by each cell type. We review the work that has been performed assessing changes in epithelial cells, stromal cells, the extracellular matrix, and immune infiltrate. To determine how these changes may be increasing breast cancer risk we also discuss the roles of each of the cell types in breast cancer initiation and progression.

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ID Code: 73645
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Mammographic density, Extracellular matrix, Stromal fibroblasts, Immune cells
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Britt et al.
Deposited On: 09 Jul 2014 22:48
Last Modified: 20 Jul 2014 02:24

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