Dielectric barrier discharge plasma in Ar/O2 promoting apoptosis behavior in A549 cancer cells

Huang, Jun, Li, Hui, Chen, Wei, Lv, Guo-Hua, Wang, Xing-Quan, Zhang, Guo-Ping, Ostrikov, Kostya, Wang, Peng-Ye, & Yang, Si-Ze (2011) Dielectric barrier discharge plasma in Ar/O2 promoting apoptosis behavior in A549 cancer cells. Applied Physics Letters, 99(25), pp. 253701-1.

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The Ar/O2plasma needle in the induction of A549 cancer cells apoptosis process is studied by means of real-time observation. The entire process of programmed cell death is observed. The typical morphological changes of A549 apoptosis are detected by 4′, 6-diamidino-2-phenylindole staining, for example, chromatin condensation and nuclear fragmentation. Cell viability is determined and quantified by neutral red uptake assay, and the survival rate of A549 from Ar/O2plasmas is presented. Further spectral analysis indicates the reactive species, including O and OH play crucial roles in the cell inactivation.

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29 citations in Web of Science®
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ID Code: 73743
Item Type: Journal Article
Refereed: Yes
DOI: 10.1063/1.3666819
ISSN: 0003-6951
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 10 Jul 2014 04:10
Last Modified: 21 Jun 2017 22:01

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