Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & (2013) Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics. Cell Stem Cell, 13(1), pp. 117-130.

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Abstract

Early full-term pregnancy is one of the most effective natural protections against breast cancer. To investigate this effect, we have characterized the global gene expression and epigenetic profiles of multiple cell types from normal breast tissue of nulliparous and parous women and carriers of BRCA1 or BRCA2 mutations. We found significant differences in CD44+ progenitor cells, where the levels of many stem cell-related genes and pathways, including the cell-cycle regulator p27, are lower in parous women without BRCA1/BRCA2 mutations. We also noted a significant reduction in the frequency of CD44+p27+ cells in parous women and showed, using explant cultures, that parity-related signaling pathways play a role in regulating the number of p27+ cells and their proliferation. Our results suggest that pathways controlling p27+ mammary epithelial cells and the numbers of these cells relate to breast cancer risk and can be explored for cancer risk assessment and prevention.

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ID Code: 73748
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Breast cancer, Molecular profiling, p27+, Mammary epithelial cells
DOI: 10.1016/j.stem.2013.05.004
ISSN: 1934-5909
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Elsevier Inc.
Copyright Statement: This is the author’s version of a work that was accepted for publication in Cell Stem Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cell Stem Cell, [VOL 13, ISSUE 1, (2013)] DOI: 10.1016/j.stem.2013.05.004
Deposited On: 10 Jul 2014 23:19
Last Modified: 30 Nov 2016 15:10

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