Anterior temporal cortex and semantic memory : reconciling findings from neuropsychology and functional imaging

Rogers, Timothy T., Hocking, Julia, Noppeney, Uta, Mechelli, Andrea, Gorno-Tempini, Maria L., Patterson, Karalyn, & Price, Cathy J. (2006) Anterior temporal cortex and semantic memory : reconciling findings from neuropsychology and functional imaging. Cognitive, Affective, and Behavioral Neuroscience, 6(3), pp. 201-213.

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Abstract

Studies of semantic impairment arising from brain disease suggest that the anterior temporal lobes are critical for semantic abilities in humans; yet activation of these regions is rarely reported in functional imaging studies of healthy controls performing semantic tasks. Here, we combined neuropsychological and PET functional imaging data to show that when healthy subjects identify concepts at a specific level, the regions activated correspond to the site of maximal atrophy in patients with relatively pure semantic impairment. The stimuli were color photographs of common animals or vehicles, and the task was category verification at specific (e.g., robin), intermediate (e.g., bird), or general (e.g., animal) levels. Specific, relative to general, categorization activated the antero-lateral temporal cortices bilaterally, despite matching of these experimental conditions for difficulty. Critically, in patients with atrophy in precisely these areas, the most pronounced deficit was in the retrieval of specific semantic information.

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ID Code: 74098
Item Type: Journal Article
Refereed: Yes
Additional Information: Rogers, Timothy T
Hocking, Julia
Noppeney, Uta
Mechelli, Andrea
Gorno-Tempini, Maria Luisa
Patterson, Karalyn
Price, Cathy J
eng
051067/Wellcome Trust/United Kingdom
MC_U105579219/Medical Research Council/United Kingdom
Comparative Study
2007/01/25 09:00
Cogn Affect Behav Neurosci. 2006 Sep;6(3):201-13.
Keywords: Brain Mapping, Humans, Image Processing, Memory/*physiology, Memory Disorders/pathology/physiopathology/radionuclide imaging, *Neuropsychological Tests, *Positron-Emission Tomography, Reaction Time, *Semantics, Temporal Lobe
DOI: 10.3758/CABN.6.3.201
ISSN: 1531-135X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Central Nervous System (110903)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurology and Neuromuscular Diseases (110904)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > COGNITIVE SCIENCE (170200) > Linguistic Processes (incl. Speech Production and Comprehension) (170204)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Copyright Owner: Copyright 2006 Springer
Deposited On: 17 Jul 2014 23:42
Last Modified: 21 Jul 2014 00:33

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