Comparison of block and event-related experimental designs in diffusion-weighted functional MRI

Williams, R.J., McMahon, K.L., Hocking, J., & Reutens, D.C. (2013) Comparison of block and event-related experimental designs in diffusion-weighted functional MRI. Journal of Magnetic Resonance Imaging, 40(2), pp. 367-375.

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To compare diffusion-weighted functional magnetic resonance imaging (DfMRI), a novel alternative to the blood oxygenation level-dependent (BOLD) contrast, in a functional MRI experiment.


Nine participants viewed contrast reversing (7.5 Hz) black-and-white checkerboard stimuli using block and event-related paradigms. DfMRI (b = 1800 mm/s2 ) and BOLD sequences were acquired. Four parameters describing the observed signal were assessed: percent signal change, spatial extent of the activation, the Euclidean distance between peak voxel locations, and the time-to-peak of the best fitting impulse response for different paradigms and sequences.


The BOLD conditions showed a higher percent signal change relative to DfMRI; however, event-related DfMRI showed the strongest group activation (t = 21.23, P < 0.0005). Activation was more diffuse and spatially closer to the BOLD response for DfMRI when the block design was used. DfMRIevent showed the shortest TTP (4.4 +/- 0.88 sec).


The hemodynamic contribution to DfMRI may increase with the use of block designs.

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3 citations in Web of Science®

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ID Code: 74099
Item Type: Journal Article
Refereed: Yes
Additional Information: Williams, Rebecca J McMahon, Katie L Hocking, Julia Reutens, David C ENG 2014/06/14 06:00 J Magn Reson Imaging. 2013 Oct 29. doi: 10.1002/jmri.24353.
Keywords: diffusion MRI, Functional MRI, experimental design
DOI: 10.1002/jmri.24353
ISSN: 1522-2586
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > STATISTICS (010400) > Applied Statistics (010401)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurosciences not elsewhere classified (110999)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Deposited On: 17 Jul 2014 23:59
Last Modified: 21 Jul 2014 00:12

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