Network-targeted combination therapy : a new concept in cancer treatment

Araujo, Robyn P., Doran, Connemara, Liotta, Lance A., & Petricoin, Emanuel F. (2004) Network-targeted combination therapy : a new concept in cancer treatment. Drug Discovery Today : Therapeutic Strategies, 1(4), pp. 425-433.

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Abstract

Toxicity is a major concern for anti-neoplastic drugs, with much of the existing pharmacopoeia being characterized by a very narrow therapeutic index. 'Network-targeted' combination therapy is a promising new concept in cancer therapy, whereby therapeutic index might be improved by targeting multiple nodes in a cell's signaling network, rather than a single node. Here, we examine the potential of this novel approach, illustrating how therapeutic benefit could be achieved with smaller doses of the necessary agents.

Impact and interest:

15 citations in Scopus
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ID Code: 74325
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.ddstr.2004.11.004
ISSN: 1740-6773
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 23 Jul 2014 23:44
Last Modified: 28 Jul 2014 00:38

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