Stress relaxation analysis of single chondrocytes using porohyperelastic model based on AFM experiments

Nguyen, Trung Dung, Oloyede, Adekunle, & Gu, YuanTong (2014) Stress relaxation analysis of single chondrocytes using porohyperelastic model based on AFM experiments. Theoretical and Applied Mechanics Letters, 4(5), 054001.

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Abstract

The aim of this study is to investigate the stress relaxation behavior of single chondrocytes using the Porohyperelastic (PHE) model and inverse Finite Element Analysis (FEA). Firstly, based on Atomic Force Microscopy (AFM) technique, we have found that the chondrocytes exhibited stress relaxation behavior. We explored the mechanism of this stress relaxation behavior and concluded that the intracellular fluid exuding out from the cells during deformation plays the most important role in the stress relaxation. Next, we have applied the inverse FEA technique to determine necessary material parameters for PHE model to simulate this stress relaxation behavior as this model is proven capable of capturing the non-linear behavior and the fluid-solid interaction during the stress relaxation of the single chondrocytes. It is observed that this PHE model can precisely capture the stress relaxation behavior of single chondrocytes and would be a suitable model for cell biomechanics.

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ID Code: 74458
Item Type: Journal Article
Refereed: Yes
Keywords: Cell biomechanics, chondrocytes, AFM, stress relaxation, Porohyperelastic (PHE) constitutive model
DOI: 10.1063/2.1405401
ISSN: 2095-0349
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Theoretical and Applied Mechanics (010207)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Funding:
Copyright Owner: Copyright 2014 Theoritical and Applied Mechanics Letters
Deposited On: 29 Jul 2014 00:26
Last Modified: 29 Jul 2015 18:36

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