BRAF inhibitors : from the laboratory to clinical trials

Rahman, M.A., Salajegheh, A., Smith, R.A., & Lam, A.K.-Y. (2014) BRAF inhibitors : from the laboratory to clinical trials. Critical Reviews in Oncology/Hematology, 90(3), pp. 220-232.

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BRAF is one of the most commonly mutated proto-oncogenes and plays a significant role in the development of numerous cancers of high clinical impact. Due to the commonality of BRAF mutations, a number of BRAF inhibitors have been developed as tools in the management of patients with cancers dependent on the action of mutant BRAF to drive cellular proliferation. In this review, we examine the current state of clinical trials and laboratory research concerning BRAF inhibitors in development and available for clinical use. We contrast the effectiveness of type-I and type-II BRAF inhibitors, the former typically showing much more restricted inhibitory selectivity and greater patient response rates.

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16 citations in Scopus
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14 citations in Web of Science®

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ID Code: 74478
Item Type: Journal Article
Refereed: Yes
Keywords: BRAF, Clinical trial, Kinase inhibitors, Multi-kinase inhibitor
DOI: 10.1016/j.critrevonc.2013.12.008
ISSN: 1879-0461
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Elsevier Ireland Ltd.
Deposited On: 28 Jul 2014 22:54
Last Modified: 29 Jul 2014 23:00

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