BRAF inhibitors : from the laboratory to clinical trials
Rahman, M.A., Salajegheh, A., Smith, R.A., & Lam, A.K.-Y. (2014) BRAF inhibitors : from the laboratory to clinical trials. Critical Reviews in Oncology/Hematology, 90(3), pp. 220-232.
BRAF is one of the most commonly mutated proto-oncogenes and plays a significant role in the development of numerous cancers of high clinical impact. Due to the commonality of BRAF mutations, a number of BRAF inhibitors have been developed as tools in the management of patients with cancers dependent on the action of mutant BRAF to drive cellular proliferation. In this review, we examine the current state of clinical trials and laboratory research concerning BRAF inhibitors in development and available for clinical use. We contrast the effectiveness of type-I and type-II BRAF inhibitors, the former typically showing much more restricted inhibitory selectivity and greater patient response rates.
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|Item Type:||Journal Article|
|Keywords:||BRAF, Clinical trial, Kinase inhibitors, Multi-kinase inhibitor|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2013 Elsevier Ireland Ltd.|
|Deposited On:||28 Jul 2014 22:54|
|Last Modified:||29 Jul 2014 23:00|
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