BRAF inhibitor therapy for melanoma, thyroid and colorectal cancers : development of resistance and future prospects

Rahman, Md Atiqur, Salajegheh, Ali, Smith, Robert A., & Lam, Alfred King-yin (2014) BRAF inhibitor therapy for melanoma, thyroid and colorectal cancers : development of resistance and future prospects. Current Cancer Drug Targets, 14(2), pp. 128-143.

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Abstract

BRAF is a major oncoprotein and oncogenic mutations in BRAF are found in a significant number of cancers, including melanoma, thyroid cancer, colorectal cancer and others. Consequently, BRAF inhibitors have been developed as treatment options for cancers with BRAF mutations which have shown some success in improving patient outcomes in clinical trials. Development of resistance to BRAF kinase inhibitors is common, however, and overcoming this resistance is an area of significant concern for clinicians, patients and researchers alike. In this review, we identify the mechanisms of BRAF kinase inhibitor resistance and discuss the implications for strategies to overcome this resistance in the context of new approaches such as multi-kinase targeted therapies and emerging RNA interference based technologies.

Impact and interest:

4 citations in Scopus
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6 citations in Web of Science®

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ID Code: 74479
Item Type: Journal Article
Refereed: Yes
Keywords: BRAF, gene therapy, kinase inhibitors, treatment resistance
DOI: 10.2174/1568009614666140121150930
ISSN: 1873-5576
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Therapy (excl. Chemotherapy and Radiation Therapy) (111204)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 28 Jul 2014 22:48
Last Modified: 29 Jul 2014 22:52

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