JK1 (FAM134B) gene and colorectal cancer : a pilot study on the gene copy number alterations and correlations with clinicopathological parameters

Kasem, Kais, Gopalan, Vinod, Salajegheh, Ali, Lu, Cu-Tai, Smith, Robert A., & Lam, Alfred King-Yin (2014) JK1 (FAM134B) gene and colorectal cancer : a pilot study on the gene copy number alterations and correlations with clinicopathological parameters. Experimental and Molecular Pathology, 97(1), pp. 31-36.

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Abstract

AIMS

The aims of the study are to characterize changes in JK-1 (FAM134B) at the DNA level in colorectal adenocarcinoma and adenoma and exploring the possible correlations with clinical and pathological features.

METHOD

JK-1 gene DNA copy number changes were studied in 211 colorectal carcinomas, 32 colorectal adenoma and 20 colorectal non-cancer colorectal tissue samples by real-time quantitative polymerase chain reaction. The results were correlated with clinical and pathological parameters.

RESULTS

Colorectal adenomas were more likely to be amplified than deleted with regard to JK-1 (FAM134B) DNA copy number change. The copy number level of JK-1 (FAM134B) DNA in colorectal adenocarcinomas was significantly lower in comparison to colorectal adenomas. Changes in JK-1 (FAM134B) DNA copy number were associated with histological subtypes, and cancer stage. Lower copy numbers were associated with higher tumor stage, lymph node stage and overall pathological stage of cancer. Conversely, higher DNA copy numbers were detected more often in the mucinous adenocarcinoma.

CONCLUSIONS

This is the first study showing significant correlations of the JK-1 (FAM134B) gene copy number alterations with clinical and pathological features in a large cohort of pre-invasive and invasive colorectal malignancies. The changes in DNA copy number associated with progression of colorectal malignancies reflect that JK-1 (FAM134B) gene could play a role in controlling some steps in development of the invasive phenotypes.

Impact and interest:

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6 citations in Web of Science®

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ID Code: 74481
Item Type: Journal Article
Refereed: Yes
Additional Information: Kasem, Kais
Gopalan, Vinod
Salajegheh, Ali
Lu, Cu-Tai
Smith, Robert A
Lam, Alfred K-Y
Exp Mol Pathol. 2014 May 11;97(1):31-36. doi: 10.1016/j.yexmp.2014.05.001.
Additional URLs:
Keywords: FAM134B, JK-1, carcinoma, colorectal
DOI: 10.1016/j.yexmp.2014.05.001
ISSN: 1096-0945
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier
Deposited On: 30 Jul 2014 00:53
Last Modified: 15 Jul 2015 03:14

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