A review of the profile of endothelin axis in cancer and its management

Irani, Soussan, Salajegheh, Ali, Smith, Robert A., & Lam, Alfred King-Yin (2014) A review of the profile of endothelin axis in cancer and its management. Critical Reviews in Oncology/Hematology, 89(2), pp. 314-321.

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Abstract

The endothelins and their associated receptors are important controllers of vascular growth, inflammation and vascular tone. In cancer, they have roles in the control of numerous factors in cancer development and progression, including angiogenesis, stromal reaction, epithelial mesenchymal transitions, apoptosis, invasion, metastases and drug resistance. Also, we consider current information on the role of this signalling system in cancer and examine the state of the current cell, animal and clinical trials utilizing endothelin targeted drugs for cancer management. Although targeting the endothelin axis in cell lines and xenografts show some promise in retarding cellular growth, results from limited clinical trials in prostatic cancer are less encouraging and did not offer significant survival benefit. The ability to target both cancer cells and vasculature via endothelin is an important consideration that necessitates the further refining of therapeutic strategies as we continue to explore the possibilities of the endothelin axis in cancer treatment.

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ID Code: 74495
Item Type: Journal Article
Refereed: Yes
Additional Information: Irani, Soussan
Salajegheh, Ali
Smith, Robert Anthony
Lam, Alfred King-Yin
Research Support, Non-U.S. Gov't
Netherlands
Crit Rev Oncol Hematol. 2014 Feb;89(2):314-21. doi: 10.1016/j.critrevonc.2013.08.011. Epub 2013 Sep 4.
Keywords: Endothelin, Cancer, Treatment, Clinical trials
DOI: 10.1016/j.critrevonc.2013.08.011
ISSN: 1879-0461
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Therapy (excl. Chemotherapy and Radiation Therapy) (111204)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Elsevier
Deposited On: 30 Jul 2014 00:29
Last Modified: 31 Jul 2014 00:02

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