Role of microRNAs in improved osteogenicity of topographically modified titanium implant surfaces

Chakravorty, Nishant (2014) Role of microRNAs in improved osteogenicity of topographically modified titanium implant surfaces. PhD by Publication, Queensland University of Technology.


This project aimed at understanding the molecular mechanisms involved in the superior integration of micro-roughened titanium implant surfaces with the surrounding bone, when compared with their smooth surfaces. It involved studying the role of microRNAs and cell signaling pathways in the molecular regulation of bone cells on topographically modified titanium dental implants. The findings suggest a highly regulated microRNA-mediated control of molecular mechanisms during the process of bone formation that may be responsible for the superior osseointegration properties on micro-roughened titanium implant surfaces and indicate the possibility of using microRNA modulators to enhance osseointegration in clinically demanding circumstances.

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ID Code: 74502
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Xiao, Yin, Oloyede, Kunle, Crawford, Ross, & Ivanovski, Saso
Keywords: cell signaling, gene expression, microarray, microRNA, micro-roughened titanium surface, modSLA, SLA, osteogenesis, osteoprogenitor differentiation, titanium surface modification
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Institution: Queensland University of Technology
Deposited On: 18 Aug 2014 23:58
Last Modified: 04 Sep 2015 01:59

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