Co-regulatory potential of vascular endothelial growth factor–A and vascular endothelial growth factor–C in thyroid carcinoma
Salajegheh, Ali, Pakneshan, Sahar, Rahman, Atiqur, Dolan-Evans, Elliot, Zhang, Sheldon, Kwong, Esther, Gopalan, Vinod, Lo, Chung-Yau, Smith, Robert A., & Lam, Alfred King-Yin (2013) Co-regulatory potential of vascular endothelial growth factor–A and vascular endothelial growth factor–C in thyroid carcinoma. Human pathology, 44(10), pp. 2204-2212.
Administrators only | Request a copy from author
Vascular endothelial growth factor (VEGF) promotes growth of blood or lymphatic vessels. The aim of the current study is to identify relationships between VEGF-A and VEGF-C, and their impact in angiogenesis and metastases in thyroid cancers. VEGF-A and VEGF-C mRNA and protein expression was investigated in 136 thyroid cancers (123 papillary thyroid carcinomas and 13 undifferentiated thyroid carcinomas) and 40 matched lymph node metastases with papillary thyroid carcinoma using reverse transcription polymerase chain reaction and immunohistochemistry. VEGF-A and VEGF-C mRNA expression was significantly different between conventional papillary thyroid carcinoma, follicular variant of papillary thyroid carcinoma, and undifferentiated thyroid carcinomas (P = 1 x 10(-6) and 1 x 10(-5), respectively). In undifferentiated carcinoma, VEGF-A and VEGF-C protein overexpression was noted in all cases. VEGF-A and VEGF-C mRNA overexpression was noted in 51% (n = 62) and 27% (n = 33) of the papillary thyroid carcinomas, whereas VEGF-A and VEGF-C protein overexpression was also identified in 70% (n = 86) and 62% (n = 76) of the carcinomas. VEGF-A mRNA was significantly higher in cancers with lymph node metastases compared with nonmetastatic cancers (P = .001), whereas most metastatic cancers underexpressed VEGF-C (P = .0002), with a similar trend for protein. The expression of VEGF-A and VEGF-C correlated with each other at both mRNA and protein levels (P = .00004 and .003, respectively). In summary, VEGF-A and -C expressions correlate with the pathological parameters and metastatic status of thyroid carcinomas. The significant correlations between the expressions of these genes add weight to hypotheses concerning VEGF-A and -C interaction in cancer progression.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||Salajegheh, Ali
Smith, Robert Anthony
Lam, Alfred King-Yin
Research Support, Non-U.S. Gov't
Hum Pathol. 2013 Oct;44(10):2204-12. doi: 10.1016/j.humpath.2013.04.014. Epub 2013 Jul 8.
|Keywords:||Adenocarcinoma, Follicular/genetics/metabolism/ secondary, Adult, Carcinoma/genetics/metabolism/ secondary, Female, Gene Expression Regulation, Neoplastic, Humans, Lymph Nodes/metabolism/pathology, Lymphatic Metastasis, Male, Middle Aged, Neovascularization, Pathologic/genetics/metabolism/ pathology, Reverse Transcriptase Polymerase Chain Reaction, Thyroid Neoplasms/genetics/metabolism/ pathology/secondary, Tumor Markers, Biological/genetics/metabolism, Vascular Endothelial Growth Factor A/genetics/ metabolism, Papillary thyroid carcinoma, Vascular Endothelial Growth Factor C/genetics/ metabolism, Undifferentiated carcinoma, VEGF-A, VEGF-C|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2013 Elsevier|
|Deposited On:||29 Jul 2014 23:06|
|Last Modified:||30 Jul 2014 23:36|
Repository Staff Only: item control page