B-Raf mutation : a key player in molecular biology of cancer
Rahman, M.A., Salajegheh, A., Smith, R.A., & Lam, A.K. (2013) B-Raf mutation : a key player in molecular biology of cancer. Experimental and Molecular Pathology, 95(3), pp. 336-42.
B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations in cancer and discuss the implications for the patient in melanoma, thyroid cancer and colorectal cancer, where B-Raf mutations are particularly common.
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|Item Type:||Journal Article|
|Additional Information:||Rahman, M A
Smith, R A
Lam, A K-Y
Exp Mol Pathol. 2013 Dec;95(3):336-42. doi: 10.1016/j.yexmp.2013.10.005. Epub 2013 Oct 23.
|Keywords:||B-Raf, BRAF, Mutation, Melanoma, Colorectal cancer, Thyroid cancer|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2013 Elsevier|
|Copyright Statement:||This is the author’s version of a work that was accepted for publication in Experimental and Molecular Pathology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Experimental and Molecular Pathology, [VOL 95, ISSUE 3, (2013)] DOI: 10.1016/j.yexmp.2013.10.005|
|Deposited On:||29 Jul 2014 22:54|
|Last Modified:||30 Jul 2015 18:33|
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