Gene amplified in oesophageal cancer 1 (GAEC1) amplification in colorectal cancers and its impact on patient's survival

Gopalan, Vinod, Yasuda, Koichi, Pillai, Suja, Tiang, Thomas, Leung, Melissa, Lu, Cu-Tai, Tang, Johnny Chuek-on, Smith, Robert A., & Lam, Alfred King-Yin (2013) Gene amplified in oesophageal cancer 1 (GAEC1) amplification in colorectal cancers and its impact on patient's survival. Journal of Clinical Pathology, 66(8), pp. 721-723.

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Abstract

GAEC1 (gene amplified in oesophageal cancer 1) is located at 7q22.1, first identified in oesophageal cancer.1 Initial work indicated that GAEC1 can act as an oncogene.2 Our pilot study found ∼80% of colorectal cancers showing amplification of GAEC1.3 In this research, we will study GAEC1 copy number in colon cancer cell lines and colorectal tissues, and its prognostic significance.

Two human colon cancer cell lines (SW480 and SW48) and one normal colonic epithelial cell line (FHC) were obtained from American Type Culture Collection. Culturing conditions for these cell lines were as published previously.4 Tissues were collected from 283 patients (213 Australian; 70 Japanese) diagnosed with colorectal cancers. Ninety surgically removed non-cancer colorectal tissues (diverticular diseases, hyperplastic polyps and volvulus) were used as controls. H&E stained sections from each cancer were checked to select a block with sufficient cancer tissue and representative morphological features for each patient for DNA extraction...

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ID Code: 74507
Item Type: Journal Article
Refereed: Yes
Additional Information: Gopalan, Vinod
Yasuda, Koichi
Pillai, Suja
Tiang, Thomas
Leung, Melissa
Lu, Cu-Tai
Tang, Johnny Chuek-on
Smith, Robert A
Lam, Alfred King-Yin
Letter
Research Support, Non-U.S. Gov't
England
J Clin Pathol. 2013 Aug;66(8):721-3. doi: 10.1136/jclinpath-2013-201459. Epub 2013 Mar 12.
Additional URLs:
Keywords: COLON, COLORECTAL CANCER, DNA
DOI: 10.1136/jclinpath-2013-201459
ISSN: 1472-4146
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 B M J Group
Deposited On: 29 Jul 2014 23:31
Last Modified: 30 Jul 2014 23:08

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