Gene amplified in oesophageal cancer 1 (GAEC1) amplification in colorectal cancers and its impact on patient's survival
Gopalan, Vinod, Yasuda, Koichi, Pillai, Suja, Tiang, Thomas, Leung, Melissa, Lu, Cu-Tai, Tang, Johnny Chuek-on, Smith, Robert A., & Lam, Alfred King-Yin (2013) Gene amplified in oesophageal cancer 1 (GAEC1) amplification in colorectal cancers and its impact on patient's survival. Journal of Clinical Pathology, 66(8), pp. 721-723.
Administrators only | Request a copy from author
GAEC1 (gene amplified in oesophageal cancer 1) is located at 7q22.1, first identified in oesophageal cancer.1 Initial work indicated that GAEC1 can act as an oncogene.2 Our pilot study found ∼80% of colorectal cancers showing amplification of GAEC1.3 In this research, we will study GAEC1 copy number in colon cancer cell lines and colorectal tissues, and its prognostic significance.
Two human colon cancer cell lines (SW480 and SW48) and one normal colonic epithelial cell line (FHC) were obtained from American Type Culture Collection. Culturing conditions for these cell lines were as published previously.4 Tissues were collected from 283 patients (213 Australian; 70 Japanese) diagnosed with colorectal cancers. Ninety surgically removed non-cancer colorectal tissues (diverticular diseases, hyperplastic polyps and volvulus) were used as controls. H&E stained sections from each cancer were checked to select a block with sufficient cancer tissue and representative morphological features for each patient for DNA extraction...
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||Gopalan, Vinod
Tang, Johnny Chuek-on
Smith, Robert A
Lam, Alfred King-Yin
Research Support, Non-U.S. Gov't
J Clin Pathol. 2013 Aug;66(8):721-3. doi: 10.1136/jclinpath-2013-201459. Epub 2013 Mar 12.
|Keywords:||COLON, COLORECTAL CANCER, DNA|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2013 B M J Group|
|Deposited On:||29 Jul 2014 23:31|
|Last Modified:||30 Jul 2014 23:08|
Repository Staff Only: item control page