Reactive Oxygen Species and Reactive Nitrogen Species in Epigenetic Modifications

Baird, Anne-Marie, O’Byrne, Kenneth J., & Gray, Steven G. (2014) Reactive Oxygen Species and Reactive Nitrogen Species in Epigenetic Modifications. In Laher, Ismail (Ed.) Systems Biology of Free Radicals and Antioxidants. Springer Berlin Heidelberg, pp. 437-455.

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For the normal homeostasis of a cell, there must be a balance between radical oxygen species/radical nitrogen species (ROS/RNS) production and the neutralization of these species by antioxidant scavenging. In times of stress, this balance is not maintained, and the result is oxidative stress. This stress can affect many pathways in the body and result in pathological consequences. Recent evidence suggests that ROS/RNS can affect the epigenetic regulation of genes by affecting the function of histone and DNA modifying enzymes, thus affecting phenotypic changes within the cellular environment. In the following chapter, we provide a broad overview of how oxidative stress induced by ROS/RNS can affect epigenetics, and using lung disease as our model we link the connection between these processes.

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ID Code: 74544
Item Type: Book Chapter
Keywords: Epigenetic regulation, Histone modifications, miRNA, RNS, ROS
DOI: 10.1007/978-3-642-30018-9_32
ISBN: 9783642300189
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 30 Jul 2014 01:03
Last Modified: 16 Jun 2016 05:21

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