Metachronous carcinomas in colorectum and its clinicopathological significance
Lam, Alfred King-Yin, Gopalan, Vinod, Carmichael, Robert, Buettner, Petra, Leung, Melissa, Smith, Robert A., Lu, Cu-Tai, Ho, Yik-Hong, & Siu, Simon (2012) Metachronous carcinomas in colorectum and its clinicopathological significance. International Journal of Colorectal Disease, 27(10), pp. 1303-1310.
Administrators only | Request a copy from author
The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients.
Over a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed.
The prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean = 66 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n = 20) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n = 11) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more often located in the proximal colon. Patients with metachronous colorectal cancers had higher prevalence of mucinous adenocarcinoma, loss of staining for MSI markers and better survival rates than other patients with colorectal cancers.
Patients with metachronous colorectal carcinomas have characteristic features, and attention to these features is important for better management of this group of cancer.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||Lam, Alfred King-Yin
Buettner, Petra Gertraud
Int J Colorectal Dis. 2012 Oct;27(10):1303-10. Epub 2012 Jul 25.
|Keywords:||Adult, Aged, Colorectal Neoplasms/genetics/ pathology, Female, Humans, Male, Microsatellite Instability, Middle Aged, Neoplasms, Second Primary/ pathology, Survival Analysis, Metachronous, Colorectal, Cancer, Carcinoma|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Oncology and Carcinogenesis not elsewhere classified (111299)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2012 Springer-Verlag|
|Deposited On:||04 Aug 2014 01:09|
|Last Modified:||05 Aug 2014 00:58|
Repository Staff Only: item control page