Metachronous carcinomas in colorectum and its clinicopathological significance

Lam, Alfred King-Yin, Gopalan, Vinod, Carmichael, Robert, Buettner, Petra, Leung, Melissa, Smith, Robert A., Lu, Cu-Tai, Ho, Yik-Hong, & Siu, Simon (2012) Metachronous carcinomas in colorectum and its clinicopathological significance. International Journal of Colorectal Disease, 27(10), pp. 1303-1310.

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The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients.


Over a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed.


The prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean = 66 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n = 20) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n = 11) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more often located in the proximal colon. Patients with metachronous colorectal cancers had higher prevalence of mucinous adenocarcinoma, loss of staining for MSI markers and better survival rates than other patients with colorectal cancers.


Patients with metachronous colorectal carcinomas have characteristic features, and attention to these features is important for better management of this group of cancer.

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8 citations in Web of Science®
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ID Code: 74548
Item Type: Journal Article
Refereed: Yes
Additional Information: Lam, Alfred King-Yin
Gopalan, Vinod
Carmichael, Robert
Buettner, Petra Gertraud
Leung, Melissa
Smith, Robert
Lu, Cu-Tai
Ho, Yik-Hong
Siu, Simon
Int J Colorectal Dis. 2012 Oct;27(10):1303-10. Epub 2012 Jul 25.
Additional URLs:
Keywords: Adult, Aged, Colorectal Neoplasms/genetics/ pathology, Female, Humans, Male, Microsatellite Instability, Middle Aged, Neoplasms, Second Primary/ pathology, Survival Analysis, Metachronous, Colorectal, Cancer, Carcinoma
DOI: 10.1007/s00384-012-1474-y
ISSN: 1432-1262
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Oncology and Carcinogenesis not elsewhere classified (111299)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Springer-Verlag
Deposited On: 04 Aug 2014 01:09
Last Modified: 22 Jun 2017 04:01

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