Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant

Smith, Robert A., Salajegheh, Ali, Weinstein, Stephen R., Nassiri, Mohammad, & Lam, Alfred King-Yin (2011) Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant. Human Pathology, 42(4), pp. 500-506.

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Abstract

Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic controversies among pathologists. The aims of this study are to (1) investigate whether follicular variant of papillary thyroid carcinoma has a different pattern of BRAF mutation than conventional papillary thyroid carcinoma in a large cohort of patients with typical features of follicular variant of papillary thyroid carcinoma and (2) to study the relationship of clinicopathological features of papillary thyroid carcinomas with BRAF mutation. Tissue blocks from 76 patients with diagnostic features of papillary thyroid carcinomas (40 with conventional type and 36 with follicular variant) were included in the study. From these, DNA was extracted and BRAF V600E mutations were detected by polymerase chain reaction followed by restriction enzyme digestion and sequencing of exon 15. Analysis of the data indicated that BRAF V600E mutation is significantly more common in conventional papillary thyroid carcinoma (58% versus 31%, P = .022). Furthermore, the mutation was often noted in female patients (P = .017), in high-stage cancers (P = .034), and in tumors with mild lymphocytic thyroiditis (P = .006). We concluded that follicular variant of papillary thyroid carcinoma differs from conventional papillary thyroid carcinoma in the rate of BRAF mutation. The results of this study add further information indicating that mutations in BRAF play a role in thyroid cancer development and progression.

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ID Code: 74627
Item Type: Journal Article
Refereed: Yes
Additional Information: Smith, Robert Anthony
Salajegheh, Ali
Weinstein, Stephen
Nassiri, Mohammad
Lam, Alfred King-Yin
Research Support, Non-U.S. Gov't
United States
Hum Pathol. 2011 Apr;42(4):500-6. doi: 10.1016/j.humpath.2009.09.023. Epub 2010 Dec 16.
Additional URLs:
Keywords: Adolescent, Adult, Aged, Base Sequence, Carcinoma, Papillary, Follicular/ genetics/ pathology, Female, Genotype, Humans, Male, Middle Aged, Molecular Sequence Data, Mutation, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Proto-Oncogene Proteins B-raf/ genetics, Thyroid Neoplasms/ genetics/ pathology, Thyroiditis, Autoimmune/genetics/pathology, Young Adult, Follicular variant, Papillary thyroid, BRAF' V600E, Lymphocytic thyroiditis, Hashimoto thyroiditis
DOI: 10.1016/j.humpath.2009.09.023
ISSN: 1532-8392
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Human Pathology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Human Pathology, [VOL 42, ISSUE 2, (2011)] DOI: 10.1016/j.humpath.2009.09.023
Deposited On: 03 Aug 2014 22:38
Last Modified: 05 Aug 2014 01:16

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