Signet-ring cell carcinoma of colorectum : current perspectives and molecular biology

Gopalan, Vinod, Smith, Robert A., Ho, Yik-Hong, & Lam, Alfred King-Yin (2011) Signet-ring cell carcinoma of colorectum : current perspectives and molecular biology. International Journal of Colorectal Disease, 26(2), pp. 127-133.

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Abstract

PURPOSE

Colorectal signet-ring cell carcinoma (SRCC) is rare, and very little detailed information on the molecular biology of the disease is available.

METHODS

The literature on the clinical, pathological and, in particular, the molecular biology of this rare entity was critically reviewed. The reviewed articles take into account a total of 1,817 cases of SRCC, but only 143 cases have molecular data available. The characteristics of two patients with colorectal SRCC were also discussed.

RESULTS

Colorectal SRCC mostly occurs in younger patients, is larger and has different site predilection compared with conventional colorectal adenocarcinoma. It can occur as one of the synchronous cancers in the colorectum. The cancer is usually diagnosed at advanced stages because of the late manifestation of symptoms, and aggressive treatment strategy is required. Limited reports in the literature have shown that the variant of colorectal cancer demonstrated a different pattern of genetic alterations of common growth kinase-related oncogenes (K-ras, BRAF), tumour suppressor genes (p53, p16), gene methylation and cell adhesion-related genes related to the Wingless signalling pathway (E-cadherin and beta-catenin) from conventional colorectal adenocarcinoma. Colorectal SRCC also showed high expression of mucin-related genes and genes related to the gastrointestinal system. There was also a higher prevalence of microsatellite instability-high tumours and low Cox-2 expression in colorectal SRCC as opposed to conventional adenocarcinoma.

CONCLUSIONS

Colorectal SRCC has unique molecular pathological features. The unique molecular profiles in SRCC may provide molecular-based improvements to patient management in colorectal SRCC.

Impact and interest:

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20 citations in Web of Science®

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ID Code: 74630
Item Type: Journal Article
Refereed: Yes
Additional Information: Gopalan, Vinod
Smith, Robert Anthony
Ho, Yik-Hong
Lam, Alfred King-Yin
Case Reports
Meta-Analysis
Review
Germany
Int J Colorectal Dis. 2011 Feb;26(2):127-33. doi: 10.1007/s00384-010-1037-z. Epub 2010 Aug 5.
Additional URLs:
Keywords: Aged, Carcinoma, Signet Ring Cell/ genetics/ pathology, Colorectal Neoplasms/ genetics/ pathology, Humans, Male, Molecular Biology, Colorectal, Signet-ring cell carcinoma
DOI: 10.1007/s00384-010-1037-z
ISSN: 1432-1262
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Springer
Deposited On: 04 Aug 2014 00:45
Last Modified: 07 Aug 2014 18:32

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