Angiogenesis in old-aged subjects after ischemic stroke : a cautionary note for investigators
Petcu, Eugen B., Smith, Robert A., Miroiu, Rodica, & Opris, Maria M. (2010) Angiogenesis in old-aged subjects after ischemic stroke : a cautionary note for investigators. Journal of Angiogenesis Research, 2(26).
Angiogenesis represents a form of neovascularisation of exceptional importance in numerous pathological conditions including stroke. In this context it is directly related to neuroregeneration which is seen in close proximity. However, numerous experimental data have been drawn from studies that have ignored the age criterion. This is extremely important as angiogenesis is different in young versus old subjects. Extrapolating data obtained from studies performed in young subjects or "in vitro" to old-age patients could lead to inexact conclusions since the dynamics of angiogenesis is age-dependent.The current review covers the key features of brain senescence including morphological and functional changes related to the brain parenchyma, its vascular network and blood flow which could possibly influence the process of angiogenesis. This is followed by a description of post-stroke angiogenesis and its relationship to neuroregeneration and its modulation by vascular endothelial growth factor (VEGF) and insulin-like growth factor 1 (IGF 1), the most important factors active in old brain after ischemic injury.
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|Item Type:||Journal Article|
|Additional Information:||Petcu, Eugen B
Smith, Robert A
Miroiu, Rodica I
Opris, Maria M
J Angiogenes Res. 2010 Nov 26;2:26. doi: 10.1186/2040-2384-2-26.
|Keywords:||stroke, Angiogenesis, neuroregeneration, aged, vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF 1),, ischemic injury|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CARDIOVASCULAR MEDICINE AND HAEMATOLOGY (110200) > Cardiovascular Medicine and Haematology not elsewhere classified (110299)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurosciences not elsewhere classified (110999)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2010 Petcu et al; licensee BioMed Central Ltd.|
|Copyright Statement:||This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
|Deposited On:||04 Aug 2014 02:53|
|Last Modified:||05 Aug 2014 00:17|
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