GAEC1 and colorectal cancer : a study of the relationships between a novel oncogene and clinicopathologic features
Gopalan, Vinod, Smith, Robert A., Nassiri, Mohammad, Yasuda, Koichi, Salajegheh, Ali, Kim, Sang Y., Ho, Yik-Hong, Weinstein, Stephen R., Tang, Johnny Chuek-on, & Lam, Alfred King-Yin (2010) GAEC1 and colorectal cancer : a study of the relationships between a novel oncogene and clinicopathologic features. Human Pathology, 41(7), pp. 1009-1015.
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GAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The copy number of GAEC1 was studied by evaluating the quantitative amplification of GAEC1 DNA in 259 colorectal tissues (144 adenocarcinomas, 31 adenomas, and 84 nonneoplastic tissues) using real-time polymerase chain reaction. Copy number of GAEC1 DNA in colorectal adenocarcinomas was higher in comparison with nonneoplastic colorectum. Seventy-nine percent of the colorectal adenocarcinomas showed amplification and 15% showed deletion of GAEC1 (P < .0001). Of the adenomas, 90% showed deletion of GAEC1, with the remaining 10% showing normal copy number. The differences in GAEC1 copy number between colorectal adenocarcinoma, colorectal adenoma, and nonneoplastic colorectal tissue are significant (P < .0001). GAEC1 copy number was significantly higher in adenocarcinomas located in distal colorectum compared with proximal colon (P = .03). In conclusion, GAEC1 copy number was significantly different between colorectal adenocarcinomas, adenomas, and nonneoplastic colorectal tissues. The copy number was also related to the site of the cancer. These findings along with previous work in esophageal cancer imply that GAEC1 is commonly involved in the pathogenesis of colorectal adenocarcinoma.
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|Item Type:||Journal Article|
|Additional Information:||Gopalan, Vinod
Smith, Robert A
Nassiri, Mohammad R
Kim, Sang Y
Tang, Johnny C-O
Lam, Alfred K-Y
Research Support, Non-U.S. Gov't
Hum Pathol. 2010 Jul;41(7):1009-15. doi: 10.1016/j.humpath.2009.11.014. Epub 2010 Mar 17.
|Keywords:||Adenocarcinoma/ genetics/metabolism, Adenoma/ genetics/metabolism, Adolescent, Adult, Aged, Colorectum, Adenocarcinoma, Child, Colorectal Neoplasms/ genetics/metabolism/pathology, Female, Gene Dosage, Humans, Male, Middle Aged, Mucins/biosynthesis, Nuclear Proteins/ genetics, Young Adult, Adenoma, GAEC1|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2010 Elsevier|
|Copyright Statement:||This is the author’s version of a work that was accepted for publication in Elsevier. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Elsevier, [VOL 41, ISSUE 7, (2010)] DOI: 10.1016/j.humpath.2009.11.014|
|Deposited On:||04 Aug 2014 02:59|
|Last Modified:||07 Aug 2014 18:05|
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