Follicular variant of papillary thyroid carcinoma : a diagnostic challenge for clinicians and pathologists

Salajegheh, A., Petcu, E. B., Smith, Robert A., & Lam, A K-Y (2008) Follicular variant of papillary thyroid carcinoma : a diagnostic challenge for clinicians and pathologists. Postgraduate medical journal, 84(988), pp. 78-82.

View at publisher

Abstract

The follicular variant of papillary thyroid carcinoma (FVPTC) presents a type of papillary thyroid cancer that has created continuous diagnosis and treatment controversies among clinicians and pathologists. In this review, we describe the nomenclature, the clinical features, diagnostic problems and the molecular biology of FVPTC. It is important for clinicians to understand this entity as the diagnosis and management of this group of patient may be different from other patients with conventional PTC. The literature suggests that FVPTC behaves in a way similar, clinically, to conventional papillary thyroid carcinoma. However, there are some genotypic differences which may characterise this neoplasm. These parameters may account for the phenotypic variation described by some scientists in this type of cancer. Further understanding can only be achieved by defining strict pathological criteria, in-depth study of the molecular biology and long term follow-up of the optional patients with FVPTC.

Impact and interest:

34 citations in Scopus
Search Google Scholar™
30 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 74636
Item Type: Journal Article
Refereed: Yes
Keywords: Carcinoma, Papillary, Follicular/ diagnosis/genetics/therapy, Diagnosis, Differential, Genes, ras/genetics, Humans, Mutation, PPAR gamma/genetics, Paired Box Transcription Factors/genetics, Proto-Oncogene Proteins B-raf/genetics, Proto-Oncogene Proteins c-ret/genetics, Thyroid Neoplasms/ diagnosis/genetics/therapy
DOI: 10.1136/pgmj.2007.064881
ISSN: 1469-0756
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Diagnosis (111202)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 04 Aug 2014 03:08
Last Modified: 04 Aug 2014 23:39

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page