Chromatic and luminance losses with multiple sclerosis and optic neuritis measured using dynamic random luminance contrast noise

Flanagan, Patrick & Zele, Andrew J. (2004) Chromatic and luminance losses with multiple sclerosis and optic neuritis measured using dynamic random luminance contrast noise. Ophthalmic and Physiological Optics, 24(3), pp. 225-233.

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We measured thresholds for detecting changes in colour and in luminance contrast in observers with multiple sclerosis (MS) and/or optic neuritis (ON) to determine whether reduced sensitivity occurs principally in red-green or blue-yellow second-stage chromatic channels or in an achromatic channel. Colour thresholds for the observers with MS/ON were higher in the red-green direction than in the blue-yellow direction, indicating greater levels of red-green loss than blue-yellow loss. Achromatic thresholds were raised less than either red-green or blue-yellow thresholds, showing less luminance contrast loss than chromatic loss. With the MS/ON observers, blue-yellow and red-green thresholds were positively correlated but increasing impairment was associated with more rapid changes in red-green thresholds than blue-yellow thresholds. These findings indicate that demyelinating disease selectively reduces sensitivity to colour vision over luminance vision and red-green colours over blue-yellow colours.

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18 citations in Scopus
16 citations in Web of Science®
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ID Code: 7478
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
DOI: 10.1111/j.1475-1313.2004.00191.x
ISSN: 0275-5408
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Blackwell Publishing
Copyright Statement: The definitive version is available at
Deposited On: 04 May 2007 00:00
Last Modified: 12 Nov 2012 23:12

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