Hybrid polymer/metal nanoparticles with surface enhanced raman tracking for potential use in nanomedicine
Dey, Priyanka (2014) Hybrid polymer/metal nanoparticles with surface enhanced raman tracking for potential use in nanomedicine. PhD by Publication, Queensland University of Technology.
This project was a preliminary step towards the development of novel methods for early stage cancer diagnosis and treatment. Diagnostic imaging agents with high Raman signal enhancement were developed based on tailored assemblies of gold nanoparticles, which demonstrated potential for non-invasive detection from deep under the skin surface. Specifically designed polymers were employed to assemble gold nanoparticles into controlled morphologies including dimers, nanochains, nanoplates, globular and core-satellite nanostructures. Our findings suggest that the Raman enhancement is strongly dependent on assembly morphology and can be tuned to adapt to the requirements of the diagnostic agent.
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|Item Type:||QUT Thesis (PhD by Publication)|
|Supervisor:||Fredericks, Peter & Waclawik, Eric|
|Additional Information:||Recipient of 2014 Outstanding Doctoral Thesis Award.|
|Keywords:||Gold nanoassemblies, Surface enhanced Raman scattering (SERS), hyperbranched polymer, diagnostic imaging agent, Reversible Addition-Fragmentation Chain Transfer, ex-vivo diagnosis, nanomedicine, ODTA|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Institution:||Queensland University of Technology|
|Deposited On:||29 Aug 2014 05:29|
|Last Modified:||04 Sep 2015 00:50|
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