The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

Lin, Quan, Wei, Wei, Coelho, Carlos M, Li, Xiang, Baker-Andresen, Danay, Dudley, Kevin, Ratnu, Vikram S, Boskovic, Zoran, Kobor, Michael S, Sun, Yi E, & Bredy, Timothy W (2011) The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nature Neuroscience, 14(9), pp. 1115-1117.

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Abstract

MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.

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ID Code: 75090
Item Type: Journal Article
Refereed: Yes
Additional URLs:
DOI: 10.1038/nn.2891
ISSN: 1546-1726
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Epigenetics (incl. Genome Methylation and Epigenomics) (060404)
Divisions: Current > Schools > School of Earth, Environmental & Biological Sciences
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2011 Nature Publishing Group
Deposited On: 14 Aug 2014 23:08
Last Modified: 18 Aug 2014 00:06

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