Artemisinin resistance in Plasmodium falciparum : a process linked to dormancy?

Cheng, Qin, Kyle, Dennis E., & Gatton, Michelle L. (2012) Artemisinin resistance in Plasmodium falciparum : a process linked to dormancy? International Journal for Parasitology: Drugs and Drug Resistance, 2, pp. 249-255.

View at publisher (open access)


Artemisinin (ART) based combination therapy (ACT) is used as the first line treatment of uncomplicated falciparum malaria in over 100 countries and is the cornerstone of malaria control and elimination programs in these areas. However, despite the high potency and rapid parasite killing action of ART derivatives there is a high rate of recrudescence associated with ART monotherapy and recrudescence is not uncommon even when ACT is used. Compounding this problem are reports that some parasites in Cambodia, a known foci of drug resistance, have decreased in vivo sensitivity to ART. This raises serious concerns for the development of ART resistance in the field even though no major phenotypic and genotypic changes have yet been identified in these parasites. In this article we review available data on the characteristics of ART, its effects on Plasmodium falciparum parasites and present a hypothesis to explain the high rate of recrudescence associated with this potent class of drugs and the current enigma surrounding ART resistance.

Impact and interest:

26 citations in Scopus
Search Google Scholar™
22 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

113 since deposited on 18 Aug 2014
84 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 75106
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Plasmodium falcipaarum, artemisinin, treatment failure, dormancy, artemisinin resistance
DOI: 10.1016/j.ijpddr.2012.01.001
ISSN: 2211-3207
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2012 Australian Society for Parasitology
Deposited On: 18 Aug 2014 02:12
Last Modified: 19 Aug 2014 00:18

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page