Artemisinin resistance in Plasmodium falciparum : a process linked to dormancy?
Cheng, Qin, Kyle, Dennis E., & Gatton, Michelle L. (2012) Artemisinin resistance in Plasmodium falciparum : a process linked to dormancy? International Journal for Parasitology: Drugs and Drug Resistance, 2, pp. 249-255.
Artemisinin (ART) based combination therapy (ACT) is used as the first line treatment of uncomplicated falciparum malaria in over 100 countries and is the cornerstone of malaria control and elimination programs in these areas. However, despite the high potency and rapid parasite killing action of ART derivatives there is a high rate of recrudescence associated with ART monotherapy and recrudescence is not uncommon even when ACT is used. Compounding this problem are reports that some parasites in Cambodia, a known foci of drug resistance, have decreased in vivo sensitivity to ART. This raises serious concerns for the development of ART resistance in the field even though no major phenotypic and genotypic changes have yet been identified in these parasites. In this article we review available data on the characteristics of ART, its effects on Plasmodium falciparum parasites and present a hypothesis to explain the high rate of recrudescence associated with this potent class of drugs and the current enigma surrounding ART resistance.
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|Item Type:||Journal Article|
|Keywords:||Plasmodium falcipaarum, artemisinin, treatment failure, dormancy, artemisinin resistance|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Public Health & Social Work
|Copyright Owner:||Copyright 2012 Australian Society for Parasitology|
|Deposited On:||18 Aug 2014 02:12|
|Last Modified:||19 Aug 2014 00:18|
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