Can estimates of antimalarial efficacy from field studies be improved?

Gatton, Michelle L. & Cheng, Qin (2008) Can estimates of antimalarial efficacy from field studies be improved? Trends in Parasitology, 24(2), pp. 68-73.

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Monitoring therapeutic efficacy of antimalarial drugs is important because treatment failure rates are the primary basis for changing antimalarial treatment policy. An important aspect of efficacy studies is the use of PCR genotyping to distinguish recrudescent from new infections. The conclusions reached using this technique might be misleading if there is insufficient parasite diversity or a non-uniform haplotype frequency distribution in the study area. Statistical techniques can be used to overcome this problem, but only when data describing the haplotype frequency distribution are available. Therefore, assessing haplotype frequency and distribution should form an integral part of all studies investigating the therapeutic efficacy of antimalarial treatment regimes.

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ID Code: 75120
Item Type: Journal Article
Refereed: Yes
Additional Information: 1471-4922 (Print) Journal Article Research Support, N.I.H., Extramural
Keywords: Alleles, Animals, Antigens, Protozoan/genetics, Antimalarials/*therapeutic use, Data Interpretation, Statistical, Drug Resistance, Gene Frequency, Genotype, Humans, Malaria, Falciparum/*drug therapy/parasitology, Malaria, Vivax/*drug therapy/parasitology, Plasmodium falciparum/classification/*drug effects/genetics, Plasmodium vivax/classification/*drug effects/genetics, Polymerase Chain Reaction, Treatment Failure, Treatment Outcome
DOI: 10.1016/
ISSN: 1471-4922
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Public Health and Health Services not elsewhere classified (111799)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Public Health & Social Work
  • NIH/AI-47500-06
Deposited On: 08 Sep 2014 00:34
Last Modified: 08 Sep 2014 23:28

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